Estimating the Respective Contributions of Human and Viral Genetic Variation to HIV Control
نویسندگان
چکیده
We evaluated the fraction of variation in HIV-1 set point viral load attributable to viral or human genetic factors by using joint host/pathogen genetic data from 541 HIV infected individuals. We show that viral genetic diversity explains 29% of the variation in viral load while host factors explain 8.4%. Using a joint model including both host and viral effects, we estimate a total of 30% heritability, indicating that most of the host effects are reflected in viral sequence variation.
منابع مشابه
P-53: Chronic Viral Infections and Infertility in Male
Background: The most common sexually transmitted diseases and the economic and social health problem throughout the world. However, vaccine coverage and antibiotic therapy and the development of programs to prevent and control major causes of acute and chronic diseases, pregnancy complications and infertility remains. Acute and chronic systemic viral infections can lead to infertility and perma...
متن کاملVenom Components of Iranian Scorpion Hemiscorpius lepturus Inhibit the Growth and Replication of Human Immunodeficiency Virus 1 (HIV-1)
Background: During the recent years, significant progress has been achieved on development of novel anti-viral drugs. Natural products are assumed as the potential sources of novel anti-viral drugs; therefore, there are some previous studies reporting the anti-viral compounds from venomous animals. Based on the significant value for tracing of non-toxic anti-viral agents from natural resources,...
متن کاملEffect of Biomolecular Conformation on Docking Simulation: A Case Study on a Potent HIV-1 Protease Inhibitor
Human immunodeficiency virus infection / acquired immunodeficiency syndrome (HIV/AIDS) is a disease pertained to the human immune system. Given its crucial role in viral replication, HIV-1 protease (HIV-1 PR) is a prime therapeutic target in AIDS therapy. In this regard, the dynamic aspects of ligand-enzyme interactions may indicate an important role of conformational variability in HIV-1 PR in...
متن کاملEffect of Biomolecular Conformation on Docking Simulation: A Case Study on a Potent HIV-1 Protease Inhibitor
Human immunodeficiency virus infection / acquired immunodeficiency syndrome (HIV/AIDS) is a disease pertained to the human immune system. Given its crucial role in viral replication, HIV-1 protease (HIV-1 PR) is a prime therapeutic target in AIDS therapy. In this regard, the dynamic aspects of ligand-enzyme interactions may indicate an important role of conformational variability in HIV-1 PR in...
متن کاملPrevalence of Major Transfusion-Transmissible Viral Infections in Blood Donors Attending Fars Blood Transfusion Center, Shiraz, Southern Iran: 2002–05
Evaluation of trends in the rate of infectious diseases of blood donors is essential for monitoring safety of blood supply and effective screening of donors. Transfusion records of blood donors who attended the Center between 2002 and 2005 were reviewed for positive cases of HBS (by ELISA), HIV (by Western Blot) and HCV (by ELISA). During 2002–05, 507,531 persons donated blood. The prevalence r...
متن کامل